The Benefits of Using Dynamic Vapour Sorption (DVS) in the Pharmaceutical Production Development

Dynamic Vapor Sorption (DVS) is a state-of-the-art gravimetric measurement tool used to measure the amount of vapor absorbed or desorbed by a material, providing valuable insights into its moisture interaction properties. It is a particularly useful technique that can be used to measure amorphous content in materials by analyzing their moisture uptake behavior, as amorphous regions typically absorb more moisture than crystalline regions under controlled conditions. The general concept of DVS is to determine the change in the weight of a material as it interacts with a controlled environment of varying humidity or solvent vapor. By precisely monitoring the sample's weight as it absorbs or desorbs vapor at different humidity levels, the DVS provides insights into the material's sorption isotherms, moisture content, and kinetics. This technique is particularly useful for understanding water sorption behavior, assessing hygroscopicity, and characterizing amorphous versus crystalline content in materials.

In DVS, there is a well-published approach for measuring the amorphous content of DVS materials. This technique is based on measuring the solvent uptake by the sample before and after the crystallization processes using a solvent that induces crystallization. The method is very specific as even minute quantities of amorphous material therein have great chances of being detected. This method is particularly beneficial for assessing the quality and shelf life of pharmaceutical products, as it helps identify and manage unstable amorphous regions that can compromise their efficacy.

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