Morphologically Directed Raman Spectroscopy

 

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Morphologically Directed Raman Spectroscopy (MDRS) combines the power of morphological imaging with the established technique of Raman Spectroscopy to deliver component-specific microstructural insight.

Morphological imaging provides a complete, detailed description of the morphological properties of particulate materials, fully characterising both spherical and irregularly shaped particles. This enables deeper understanding of a sample’s characteristics through precise detection of agglomerates, foreign particles, and other anomalous materials.

Morphological imaging precisely characterizes individual particles within pre-dispersed samples of dry powders, wet suspensions, and particulates deposited on filters. Statistically representative distributions are constructed by rapidly and automatically analysing hundreds of thousands of particles per measurement, providing valuable information on the whole sample.

Morphologi 4-ID

Applications & properties measured with Morphologically Directed Raman Spectroscopy

Active Pharmaceutical Ingredient (API) and excipient particle size and shape are critical material attributes which must be understood and controlled during formulation development and process scale-up for both innovator and generic products. Morphologi delivers the data required to achieve this, and can also determine the component-specific API particle size required to establish in vitro bioequivalence for generics, minimizing associated clinical study costs.

Metal powder properties such as particle size and shape are critical for powder metallurgy processes as they impact final component quality and performance. Morphologi is used by metal powder producers and component manufacturers to ensure an optimum, consistent and traceable powder supply, mitigating the risk of costly part failure.

Cement is a complex mixture of minerals and additives, the component-specific particle properties of which affect final product performance. The capability of the Morphologi 4-ID system to analyse and characterize specific particle populations within a cement blend enables different batches or products to be compared, aiding product development and solving production problems.

The processing of pharmaceutical materials is known to introduce small amounts of amorphous material, which can dramatically affect product stability, compatibility, processing and storage. It is thus critical that pharmaceutical scientists have the ability to accurately and precisely measure amorphous content, particularly at low levels.

The most common measurement of amorphous structure involves the analysis of the glass transition by DSC. It is important to examine both the size of the transition in heat flow or heat capacity units and the temperature (Tg) at which it occurs. The size of the transition provides quantitative information about the amount of amorphous structure in the sample, and the temperature identifies the point where there is a dramatic change in physical properties.

Specific surface area is typically described in units of m2/g and BET is the most common model for the calculation of surface area. One of the routine experiments carried out by the DVS is to calculate BET surface area of materials using organic vapors as probe molecules. The traditional BET determination includes nitrogen sorption under vacuum conditions. The DVS overcomes these limitations by using a range of organic probe molecules for sorption which can be carried out at ambient and varied temperatures as well as under ambient pressure or under vacuum. This has the advantage of calculating BET surface areas under real conditions, which is useful for material application.

Dynamic Vapor Sorption is a gravimetric technique used to measure the sorption properties of materials using water and organic vapors, used to characterise complex materials used in a range of industries.

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