Thermal Monitoring Activity

 

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Given the association of either heat production or heat consumption in all chemical, physical, and biological processes, the ability to measure and quantify universal heat signals is vital to understanding any material.

Thermal activity monitoring (TAM) microcalorimetry is one of the most sensitive calorimetric techniques for this kind of analysis, capable of measuring heat effects over time in most chemical, physical and biological processes. By monitoring heat flow with incredible detail and accuracy with long term temperature stability, processes can be measured that are undetectable by other techniques.


TAM IV

Applications & properties measured with Thermal Activity Monitoring

These experiments are performed by dissolving the solid sample material in a solvent and measuring the temperature rise or fall in the solvent as a result such dissolution. Considering that amorphous and crystalline materials will have a different heat of dissolution, a direct comparison allows the quantification of the amount of amorphous material present in a mixture of crystalline and amorphous material.

Isothermal heat flow measurements of pharmaceuticals are a fast and reliable way to characterize the stability of a drug and its formulation. The technique can detect chemical and physical changes within a sample that may affect its performance at any point during the development process and/or during storage conditions.

Specific surface area is typically described in units of m2/g and BET is the most common model for the calculation of surface area. One of the routine experiments carried out by the DVS is to calculate BET surface area of materials using organic vapors as probe molecules. The traditional BET determination includes nitrogen sorption under vacuum conditions. The DVS overcomes these limitations by using a range of organic probe molecules for sorption which can be carried out at ambient and varied temperatures as well as under ambient pressure or under vacuum. This has the advantage of calculating BET surface areas under real conditions, which is useful for material application.

Dynamic Vapor Sorption is a gravimetric technique used to measure the sorption properties of materials using water and organic vapors, used to characterise complex materials used in a range of industries.

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